Original Article The Effect of Steroid in the Treatment of Simple Bone Cysts in Comparison with Autogenous Bone Marrow Injection
Management of bone cysts with steroids
Keywords:
Autogenous bone marrow injection, simple bone cyst, steroid injectionAbstract
Background: Simple bone cysts (SBC) are well-known lesions; however, there is currently no cure for them. Studies using a
common treatment technique – steroid injection – reported results that were quite diverse from one another. The outcomes of patients
with pathological fractures who were not on any treatment were evaluated in comparison to the steroid injection method. Materials
and Methods: A total of 44 patients had steroid injection therapy (Group – I) and 38 were treated with autogenous bone marrow
injection (ABMI). For comparisons, Capanna’s plain radiographic evaluation criteria were applied, and magnetic resonance imaging
(MRI) was utilized. The outcomes were graded in accordance with MRI and X-ray findings. Results: The first and most important
finding was that the majority of ABMI patients responded well following their initial injection. We discovered that the majority of
patients fell within the range of 5 months–1 year, taking into consideration the time between the start of conservative treatment and
the mechanical repair of the cyst (CI lower than 3 and cortical width lower than 2 mm). Conclusion: Failure after a steroid injection
is possible, and healing before the third injection only rarely happens, ABMI is a straightforward, cost-free procedure that works on
both active and dormant cysts, and in the majority of cases, after the initial injection, certain symptoms of healing appear.
References
REFERENCES
Cohen J. Simple bone cysts. Studies of cyst fluid in six
cases with a theory of pathogenesis. J Bone Joint Surg Am
;42-A:609-16.
Zhao JG, Wang J, Huang WJ, Zhang P, Ding N, Shang J.
Interventions for treating simple bone cysts in the long bones of
children. Cochrane Database Syst Rev 2017;2017:CD010847.
Deventer N, Deventer N, Gosheger G, de Vaal M, Vogt B,
Budny T. Current strategies for the treatment of solitary and
aneurysmal bone cysts: A review of the literature. J Bone
Oncol 2021;30:100384.
Zhang P, Zhu N, Du L, Zheng J, Hu S, Xu B. Treatment of
simple bone cysts of the humerus by intramedullary nailing
and steroid injection. BMC Musculoskelet Disord 2020;21:70.
Flont P, Kolacinska-Flont M, Niedzielski K. Factors predictive
of positive response to steroid therapy in simple bone cysts: An
old trick that still works. Int Orthop 2013;37:1519-25.
Hashemi-Nejad A, Cole WG. Incomplete healing of simple
bone cysts after steroid injections. J Bone Joint Surg Br
;79:727-30.
Rahman MA, El Masry AM, Azmy SI. Review of 16 cases
Table 2: Success rates comparison based on MRI findings
Rades Steroid group ABMI group P‑value
Success: n=24 Failure: n=20 Success: n=29 Failure: n=9
Number Percent Number Percent
Healed 6 0 23 0 0.03
With residual 18 0 6 0 0.04
Recurrent 0 10 0 5 0.06
Persistent 0 10 0 4 0.06
ABMI: Autogenous bone marrow injection, MRI: Magnetic resonance imaging
Shah and Ajri: Management of bone cysts with steroids
Journal of Bones and Muscles Health • Vol 1 • Issue 1 • 2023
of aneurysmal bone cyst in the proximal femur treated by
extended curettage and cryosurgery with reconstruction using
autogenous nonvascularized fibula graft. J Orthop Surg (Hong
Kong) 2018;26:2309499018783905.
Zamzam MM, Abak AA, Bakarman KA, Al-Jassir FF,
Khoshhal KI, Zamzami MM. Efficacy of aspiration and
autogenous bone marrow injection in the treatment of simple
bone cysts. Int Orthop 2009;33:1353-8.
Datta NK, Das KP, Alam MS, Kaiser MS. Management of
unicameral bone cyst by using freeze dried radiation sterilized
bone allograft impregnate with autogenous bone marrow.
Mymensingh Med J 2014;23:512-9.
Ulici A, Balanescu R, Topor L, Barbu M. The modern treatment
of the simple bone cysts. J Med Life 2012;5:469-73.
Docquier PL, Delloye C. Treatment of aneurysmal bone cysts
by introduction of demineralized bone and autogenous bone
marrow. J Bone Joint Surg Am 2005;87:2253-8.
Pradel W, Eckelt U, Lauer G. Bone regeneration after
enucleation of mandibular cysts: comparing autogenous grafts
from tissue-engineered bone and iliac bone. Oral Surg Oral
Med Oral Pathol Oral Radiol Endod 2006;101:285-90.
Hunt KJ, Bergeson A, Coffin CM, Randall RL. Percutaneous
curettage and bone grafting for humeral simple bone cysts.
Orthopedics 2009;32:89.
Cho HS, Seo SH, Park SH, Park JH, Shin DS, Park IH.
Minimal invasive surgery for unicameral bone cyst using
demineralized bone matrix: A case series. BMC Musculoskelet
Disord 2012;13:134.
Hou HY, Wu K, Wang CT, Chang SM, Lin WH, Yang RS.
Treatment of unicameral bone cyst: A comparative study of
selected techniques. J Bone Joint Surg Am 2010;92:855-62.

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